EBV nuclear antigen (EBNA-IgG) antibodies develop later (after 2 to 4 months ) in acute EBV infection and also persist for life. IgG VCA (EBV VCA-IgG) also develops early in primary EBV infection, but these antibodies persist for life. The presence of IgM antibodies to the EBV viral capsid antigen (VCA) indicates primary EBV infection (these antibodies disappear within 3 months after infection). However, very high atypical lymphocyte counts are typically seen only in primary EBV and CMV infection.ĮBV-specific antibody testing is highly sensitive. read more, or other viral illnesses, so diagnosis requires serologic testing. read more, rubella Rubella ( See also Congenital Rubella.) Rubella is a contagious viral infection that may cause adenopathy, rash, and sometimes constitutional symptoms, which are usually mild and brief. Mortality is possible during seasonal epidemics, particularly among high-risk patients (eg, those. read more, influenza B Influenza Influenza is a viral respiratory infection causing fever, coryza, cough, headache, and malaise. It causes typical symptoms of viral hepatitis, including anorexia, malaise, and jaundice. read more infection, hepatitis B Hepatitis B, Acute Hepatitis B is caused by a DNA virus that is often parenterally transmitted. A syndrome of infectious mononucleosis that lacks severe pharyngitis is common. read more or CMV Cytomegalovirus (CMV) Infection Cytomegalovirus (CMV, human herpesvirus type 5) can cause infections that have a wide range of severity. Atypical lymphocytes may also be present in HIV Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. Although individual lymphocytes may resemble leukemic lymphocytes, lymphocytes are heterogeneous, which is unlikely in leukemia Overview of Leukemia Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. Lymphocytes that are morphologically atypical account for up to 30% of the white blood cells. Laboratory diagnosis usually involves a complete blood count and EBV serologic testing.
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